姚后宗

发布者:李素珍发布时间:2022-10-09浏览次数:700

后宗 博士


硕士研究生导师(生物与医药)

学习经历

2017.06 – 2021.10香港城市大学,化学,博士

2012.09 – 2015.06苏州大学,药物化学,硕士

2008.09 – 2012.06苏州大学,药学,学士

工作经历

2022.04 – 今,maxbextx官方网站手机登录|首頁|欢迎您健康学院硕导

2022.02 – 2022.05,香港城市大学深圳研究员,副研究员

2015.12 – 2017.05,香港浸会大学中医药学院(高级)研究助理

研究兴趣

铂类金属抗癌药的合成、生物活性与机理研究

科研项目

maxbextx官方网站手机登录|首頁|欢迎您优秀海归科研启动项目120218812022.04 – 2027.0350万元,主持

国家自然科学基金面上项目(22077108),2021.01 – 2024.1263万元,参与

国家自然科学基金面上项目(21877092),2019.01 – 2022.1267万元,参与

代表性论文

H. Yao, Z. Wang, N. Wang, Z. Deng, G. Liu, J. Zhou, S. Chen, J. Shi, G. Zhu.Enhancing circulation and tumor accumulation of carboplatin via an erythrocyte-anchored prodrug strategy.Angew. Chem. Int. Ed.2022, e202203838. [Impact Factor = 16.8]

H. Yao, S. Chen, Z. Deng, M.-K. Tse, Y. Matsuda, G. Zhu.BODI-Pt, a green-light-activatable and carboplatin-based platinum (IV) anticancer prodrug with enhanced activation and cytotoxicity. Inorg. Chem.2020, 59, 11823−11833.

H. Yao, Z. Xu, C. Li, M.-K. Tse, Z. Tong, G. Zhu.Synthesis and cytotoxic study of a platinum (IV) anticancer prodrug with selectivity toward luteinizing hormone-releasing hormone (LHRH) receptor-positive cancer cells. Inorg. Chem.2019, 58, 11076−11084.

H. Yao, G. Zhu. A platinum-based fluorescent "turn on" sensor to decipher the reduction of platinum(IV) prodrugs. Dalton Trans.2022, 51, 5394−5398. [Highlighted as Outside Front Cover]

H. Yao, Y. F. Gunawan, G. Liu, M.-K. Tse, G. Zhu. Optimization of axial ligands to promote the photoactivation of BODIPY-conjugated platinum (IV) anticancer prodrugs. Dalton Trans.2021, 50, 13737−13747.

H. Yao, F. Jiang, A. Lu, G. Zhang.Methods to design and synthesize antibody-drug conjugates (ADCs). Int. J. Mol. Sci. 2016, 17, 194.

H. Yao, F. Liu, J. Chen, Y. Li, J. Cui, C. Qiao.Antischistosomal activity of N,N'-arylurea analogs against Schistosoma japonicum. Bioorg. Med. Chem. Lett.2016, 26, 13861390.

S. Ni,H. Yao, L. Wang, J. Lu, F. Jiang, A. Lu, G. Zhang.Chemical modifications of nucleic acid aptamers for therapeutic purposes.Int. J. Mol. Sci. 2017, 18, 1683.

姚后宗,尹伟,陈晶磊,乔春华. 一种氟代丁酸腺苷衍生物的合成.有机化学. 2014, 34, 12221226.

代表性

ZDeng, H. Yao, Z. Wang, G. Zhu.Platinum anticancer drugs: Targeting and delivery, in Comprehensive Inorganic Chemistry III (Eds.: J. Reedijk, K. Poeppelmeier), Under Proof.

联系方式

地址:江西省南昌市紫阳大道99号maxbextx官方网站手机登录|首頁|欢迎您健康学院

电话:18070595232

E-mailyaohz@jxnu.edu.cn